Naslov (srp)

Antitumorski efekat bakar(II) kompleksa sa azot-kiseoničnim donorskim ligandima na ćelije multiformnog glioblastoma in vitro

Autor

Babić, Saša, 1977-

Doprinosi

Čanović, Petar, 1989-
Kostić, Marina, 1981-
Zarić, Milan, 1982-
Čobeljić, Božidar, 1983-
Jovanović, Mirjana, 1968-

Opis (srp)

Multiformni glioblastom predstavlja najčešći i najagresivniji primarnitumor centralnog nervnog sistema sa prosečnim preživljavanjem od momentapostavljanja dijagnoze 15 meseci. Standarna terapija multiformnog glioblastomapodrazumeva hirušku intervenciju, radioterapiju i hemioterapiju. Od citostatikakoristi se temozolomid, neželjena dejstva ovog leka su posledica neselektivnosti, pase može javiti supresija koštane srži, kardiotoksičnost, hepatotoksičnost,nefortoksičnost. Iz prethodno navedenih činjeica, možemo zaključiti da bi razvitakpotencijalnih citostatika mogao da pomogne u efikasnijoj terapiji multiformnogglioblastoma.Cilj ovog istraživanja jeste ispitivanje antitumorskog dejstvanovosintetisanih bakar(II) jedinjenja na tumorske ćelijske linije U251, HeLa iHCT116, kao i na maligo neizmenjene fibroblaste MRC-5. Sintetisana jedinjenjabakra Su1 i Cu2 su demonstrirala signifikantan antikancerski efekat natestiranim HCT116, HeLa, U251 ćelijama uz veliki stepen selektivnosti premamaligno neizmenjenim ćelijama fibroblastima.Snažan citotokični efekat dva jedinjenja bakra na ćelije multifomrnogglioblastoma je postignut indukcijom rane apoptoze, promenom odnosa Bcl2/Baxmolekula.Primenjeni bakarni kompleksi dovodili su do narušavanja normalnog protokaćelijskog ciklusa u kancerskim U251 ćelijama, što je rezultiralo značajnimsmanjenjem stope njihovog preživljavanja.

Opis (srp)

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Opis (eng)

Glioblastoma multiforme represents the most common and aggressive primary tumorof the central nervous system, with an average survival of 15 months from the time ofdiagnosis. Standard therapy for glioblastoma multiforme includes surgical intervention,radiotherapy, and chemotherapy. Among cytostatics, temozolomide is commonly used;however, the adverse effects of this drug result from its non-selectivity, which may lead tobone marrow suppression, cardiotoxicity, hepatotoxicity, and nephrotoxicity. Based on thesefacts, it can be concluded that the development of potential cytostatics could contribute tomore effective therapy for glioblastoma multiforme.The aim of this study was to investigate the antitumor activity of newly synthesizedcopper(II) compounds on tumor cell lines U251, HeLa, and HCT116, as well as on nonmalignant fibroblasts MRC-5. The synthesized copper compounds Cu1 and Cu2demonstrated a significant anticancer effect on the tested HCT116, HeLa, and U251 cells,with a high degree of selectivity toward non-malignant fibroblast cells.The strong cytotoxic effect of the two copper compounds on glioblastoma multiformecells was achieved through the induction of early apoptosis and alteration of the Bcl2/Baxmolecular ratio. The applied copper complexes also led to disruption of normal cell cycleprogression in cancerous U251 cells, resulting in a significant reduction in their survival rate.

Jezik

srpski

Datum

2026

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY-NC 3.0 AT - Creative Commons Autorstvo - Nekomercijalno 3.0 Austria License.

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