Naslov (srp)

Fenotipske karakteristike glatkih mišićnih ćelija u arterijama osoba sa uznapredovalim formama ateroskleroze

Autor

Rosić, Vesna, 1983-

Doprinosi

Tanasković, Irena, 1973-
Stanković, Vesna, 1964-
Sazdanović, Maja, 1974-
Milovanović, Jelena, 1981
Labudović Borović, Milica, 1971-

Opis (eng)

The subject of this research is the evaluation of the role of cytohistological factors that contributeto the pathogenesis of atherosclerosis. The research will include the characteristics of differentstages of atherosclerosis, cytohistological and immunohistochemical analysis of atheroscleroticchanges, as well as determining the possible association of other factors with the clinical pictureof patients.A retrospective clinical-histopathological case-control study has been planned. The study willinclude 21 samples in the case group and 41 samples in the control group. The case groupconsists of samples of coronary arteries of deceased persons with advanced types ofatherosclerosis. The control group consists of samples of coronary arteries of deceased personswith early lesions of atherosclerosis.The study will analyze the cytohistological characteristics of the stage of atherosclerosisaccording to the classification of the American Heart Association Committee on Vascular Lesionsof the Council of Atherosclerosis, immunohistochemical characteristics by using fourimmunohistochemical markers - α-smooth muscle actin, S-100 protein, desmin and vimentin, aswell as a larger number of variables obtained from medical histories.The determination of the most significant cytohistological factors that lead to the progression ofcoronary artery atherosclerosis is expected to be the most important result of this study. Inaddition, the results of the immunohistochemical analysis in this study could indicate theassociation between the clinical picture of coronary disease and its cytohistologicalcharacteristics, that is, the stage of atherosclerosis.

Opis (srp)

Predmet ovog istraživanja je evaluacija uloge citohistoloških faktora koji doprinosepatogenezi ateroskleroze. Istraživanje će obuhvatiti karakteristike različitih fazaateroskleroze, citohistološku i imunohistohemijsku analizu aterosklerotičnihpromena, kao i utvrđivanje moguće povezanosti drugih faktora sa kliničkom slikompacijenata.Planirana je retrospektivna kliničko-histopatološka studija tipa slučaj-kontrola.Studija će obuhvatiti 21 uzorak u grupi slučajeva i 41 uzorak u grupi kontrola. Grupuslučajeva čine uzorci koronarnih arterija umrlih, sa uznapredovalim formamaateroskleroze. Grupu kontrola čine uzorci koronarnih arterija umrlih, sa ranimlezijama ateroskleroze.U studiji će biti analizirane citohistološke karakteristike stadijuma aterosklerozeprema klasifikaciji American Heart Association Committee on Vascular Lesions of theCouncil of Atherosclerosis, imunohistohemijske karakteristike korišćenjem četiriimunohistohemijska markera – α-glatkomišićni aktin, S-100 protein, dezmin ivimentin, kao i veći broj varijabli dobijenih iz istorija bolesti.Kao najvažniji rezultat ove studije očekuje se utvrđivanje najznačajnijihcitohistoloških faktora koji vode progresiji ateroskleroze koronarnih arterija. Osimtoga, rezultati imunohistohemijske analize u ovoj studiji mogli bi da ukažu napovezanost kliničke slike koronarne bolesti i njenih citohistoloških karakteristika,odnosno, stadijuma ateroskleroze.

Opis (srp)

-

Jezik

srpski

Datum

2023

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY-NC-ND 3.0 AT - Creative Commons Autorstvo - Nekomercijalno - Bez prerada 3.0 Austria License.

http://creativecommons.org/licenses/by-nc-nd/3.0/at/legalcode