Naslov (srp)

Ispitivanje efikasnosti akrilata modifikovanog antigljivičnim supstancama u sprečavanju kolonizacije proteza gljivama roda Candida

Autor

Išljamović, Milica, 1982-, 69688841

Doprinosi

Todić, Jelena, 1974-, 57660425
Živković, Rade, 1964-, 12679527
Otašević, Suzana, 1961-, 7315559
Milosavljević, Marko, 1980- , 24479079

Opis (eng)

Introduction: Wearing denture is accompained with colonisation of Candida spp. and the development of Candida-associated denture stomatitis. The problem in therapy is fungal resistance and the inability to achieve effective antifungal concentrations on denture. Aim is to modify cold-curing acrylic resin (PMMA) for denture lining with antifungal substances (AS): undecylenic acid (UA), farnesol (F) or their combination (UA + F), to study the physico-chemical properties of the modified acrylates (MA), cytotoxicity and its antifungal effect on Candida (C.) albicans ATCC 90028. Material and methods: physico-chemical characterization of the MA surface was characterized by Fourier transform infrared spectroscopy (FTIR), by measuring the water contact angle; toxicity of the MA was tested by using the 3-(4,5-dimethylthiazol-2-yl)-5-(3- carboxymethoxypenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) test, while antifungal activity was elavuated by disc diffusion test. The effect of the MA on sessile and planktonic C. albicans cells was examined using XTT (2,3-bis(2-methoxy-4-nitro-5-sulfo-phenyl)-2Htetrazolium-5-carboxanilide) reduction assay. Results: Аntifungal substances were observed on the surface of MA and significantly reduced the contact angle compared to control (PMMA). AS are not cytotoxic in a concentration that will affect the reduction of metabolically active planktonic and sessile C. albicans cells on the МА surface. UA+F combination allows the application of lower concentrations of AS in PMMA. AS inhibit transition of C. albicans cells from yeast to filamentous form. Conclusion: Modified cold-curing acrylic resin for dentures lining could improve the treatment of denture stomatitis.

Opis (srp)

Uvod: Nošenje zubne proteze je predisponirajući faktor za razmnožavanje gljiva roda Candida na oralnoj mukozi i razvoj proteznog stomatitisa. Problem u terapiji proteznog stomatitisa je rezistencija gljiva i nemogućnost postizanja efikasnih koncentracija antimikotika na protezi. Cilj je izvršiti modifikaciju hladnopolimerizujućeg akrilata (PMMA) za podlaganje zubnih proteza dodavanjem antigljivičnih supstanci (AS): undecileinske kiseline (UK), farnezola (F) ili njihove kombinacije (UK+F); ispitati fizičkohemijske osobine modifikovanih akrilata (MA), citotoksičnost i antifungalni efekat na soj Candida (C.) albicans ATCC 90028. Materijal i metode: fizičko-hemijska karakterizacija površine MA je urađena pomoću totalne refleksije u infracrvenoj spektroskopiji sa Furijeovom transformacijom (FTIR) i merenjem vodenog kontaktnog ugla površine MA. Citotoksičnost MA je ispitana pomoću MTS-[3-(4,5-dimetiltiazol-2-il)-5-(3- karboksimetoksifenil)-2-(4-sulfofenil)-2H-tetrazolijum] testa, a antigljivična aktivnost testom disk difuzije. Efekat MA na sesilne i planktonske ćelije gljiva vrste C.albicans je ispitan pomoću XTT [2,3-bis (2-metoksi–4–nitro–5–sulfofenil)- 2H-tetrazolium-5-karboksanilid)] testa. Rezultati: Antigljivične supstance su prisutne na površini MA i značajno povećavaju hidrofilnost u odnosu na kontrolu. AS nisu ispoljile citotoksičnost u koncentraciji koja utiče na redukciju metabolički aktivnih planktonskih i sesilnih ćelija vrste C. albicans na površini MA. Kombinacija UK+F omogućava primenu nižih koncentracija AS u PMMA. Ove supstance prisutne u agaru sprečavaju prelazak vrste C. albicans u filamentoznu formu rasta. Zaključak: modifikovani hladnopolimerizujući akrilati za podlaganje zubnih proteza bi mogli da unaprede tretman proteznog stomatitisa izazvanog gljivama roda Candida.

Jezik

srpski

Datum

2020

Licenca

Creative Commons licenca
Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY-NC-ND 2.0 AT - Creative Commons Autorstvo - Nekomercijalno - Bez prerada 2.0 Austria License.

CC BY-NC-ND 2.0 AT

http://creativecommons.org/licenses/by-nc-nd/2.0/at/

Identifikatori