Naslov (srp)

Uticaj telesnih i viscelralnih masti na tok i ishod bolesti COVID-19 hospitalizovanih pacijenata

Autor

Stevanović, Đorđe, 1992-

Doprinosi

Zdravković, Vladimir, 1973-
Ćupurdija, Vojislav, 1976-
Marjanović, Sonja S., 1965-
Vučić, Rada, 1979-

Opis (srp)

Uvod: tačan uticaj gojaznosti na tok i ishod COVID-19 ostaje nedovoljno ispitan, a kaojedno od glavnih objašnjenja navodi se samostalna upotreba ITM u definisanjugojaznosti u većini istraživanja, čime se zanemaruje uticaj zastupljenosti i raspodelemasnog tkiva.Ciljevi: primarni cilj studije bio je ispitivanje uticaja telesnih i visceralnihmasti na razvoj kritične forme bolesti i mortalitet hospitalizovanih COVID-19pacijenata.Metodologija: klinička opservaciona, prospektivna studija sprovedena je na 216adultnih, SARS-CoV-2 pozitivnih pacijenata, hospitalizovanih u UniverzitetskomKliničkom Centru Kragujevac (Kragujevac, Srbija) u periodu od oktobra 2021. dojanuara 2022. godine. Unutar 24 časa od prijema u bolnicu, pacijenti su rutinskiuzrokovani za arterijske gasne analize i laboratorijske analize. Dodatno, unutar 72časa od prijema, pacijentima su sprovedena somatometrijska merenja, koja su, osimITM, uključivala i parametre dobijene analizom bioelektrične imdedance - %TM inivo VM. Pacijenti su praćeni tokom trajanja hospitalnog lečenja.Rezultati: većina pacijenata imala je narušen status uhranjenosti u smeru gojaznosti:39,3% po ITM, odnosno 50,9% po %TM, dok je veoma visok nivo VM imalo 38,4%ispitanika. Veoma visok nivo %TM i VM bili su nezavisni prediktori razvojakritične forme bolesti (aOR 6,55, odnosno 2,10) i mortaliteta (aOR 3,36, odnosno2,54). Iako je postojanje gojaznosti po ITM nosilo tri puta veći rizik od razvojakritične forme (aOR 3,14), ITM se nije izdvojio kao nezavisni prediktormortaliteta.Zaključak: procena statusa uhranjenosti metodom bioelektrične impedance može bitikorisna u ranoj proceni visoko-rizičnih COVID-19 pacijenata

Opis (srp)

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Opis (eng)

Introduction: the data regarding the exact impact of obesity on COVID-19 are inconsistent.One of the possible explanations are sole use of BMI in defining obesity, thus neglecting thepresence and distribution of adipose tissue.Aim: the primary aim was to examine the impact of total body and visceral fat on mortalityand critical form development among hospitalized COVID-19 patients.Method: observational, prospective study was conducted on 216 adult, SARS-CoV-2 positivepatients, hospitalized in the University Clinical Center Kragujevac, between October 2021. andJanuary 2022. Within 24 hours upon admission patients were routinely sampled for laboratoryand blood gas analysis. Additionally, within 72 hours upon admission, somatometricmeasurements were performed. They included BMI and parameters obtained from bioelectricalimpedance analysis - BF% and VF levels. Patients were followed during the hospitalizationperiod.Results: majority of patients had disturbed body composition in terms of obesity: 39.3%according to BMI and 50.9% according to BF%, while 38.4% of patients had very high VFlevels. Very high BF% and VF were independent predictors of critical form development (aOR6.55 and 2.10, respectively) and mortality (aOR 3.36 and 2.54, respectively). Although thepresence of obesity according to BMI carried a three time greater risk of critical formdevelopment (aOR 3.14), BMI was not singled out as an independent predictor of mortality.Conclusion: accessing body composition using the bioelectrical impedance method could beuseful in early recognition of high-risk hospitalized COVID-19 patients.

Jezik

srpski

Datum

2024

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY-NC-ND 3.0 AT - Creative Commons Autorstvo - Nekomercijalno - Bez prerada 3.0 Austria License.

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