Title (srp)

Numerička i eksperimentalna analiza kardiomiopatije

Author

Tomašević, Smiljana, 1992-

Contributor

Filipović, Nenad, 1970-
Isailović, Velibor, 1980-
Jovičić, Gordana, 1967-
Velicki, Lazar, 1980-
Saveljić, Igor, 1983-
Davidović, Goran, 1968-

Description (eng)

Although numerous clinical studies have been conducted and guidelines of goodclinical practice have been established, there are lacks in understanding the mechanisms ofcardiomyopathy progression, stratifying patients into low- and high-risk groups, as well asdetermining and monitoring the effects of therapies for each individual patient. Monitoringof cardiomyopathy progression and associated aortopathy, as well as the effects of drugs onthe myocardium, highlights the need for development of new methods to better understandcardiac functions.The presented dissertation includes the analysis of hypertrophic and dilatedcardiomyopathy, as well as associated diseases related to different degrees of aortic stenosisaffecting cardiac hypertrophy. Different three-dimensional (3D) parametric models of theleft heart ventricle are created, as well as the 3D patient-specific models of aortic root andthe whole heart. Part of the data from the conducted clinical and experimental studies ofcardiomyopathy are used for the development and validation of numerical models, riskstratification of cardiomyopathy, as well as for modeling the effects of different drug groupson cardiac function.Computational simulations including 3D parametric models of the left heart ventricleare performed using coupled micro- and macromodels, employing the finite element methodand fluid-solid interaction. Drugs interactions with cardiomyocytes are determined withinthe experimental studies of heart tissue, while the results are implemented in a coupledmultiscale model to determine the effects of different drug groups on a 3D model of the leftheart ventricle. Active and passive muscle models are implemented. The influence ofdifferent aortic stenosis severities on fluid and solid behaviour was simulated on patientspecific models, whereas its association with cardiac hypertrophy and aortopathy wasdiscussed. The presented methods and results of computational simulations for differenttypes of cardiomyopathies and associated cardiovascular diseases will have a significantimpact on clinical guidelines and future directions of patients’ treatments.

Description (srp)

Iako su sprovedene brojne kliničke studije i postavljene smernice dobrekliničke prakse, nedostaci u razumevanju mehanizama napredovanjakardiomiopatije, stratifikaciji pacijenata u nisko- i visoko-rizične grupe, kao iu određivanju i praćenju dejstva terapija za svakog pojedinačnog pacijenta i daljepostoje. Praćenje progresije kardiomiopatije i pridružene aortopatije, kao iefekata lekova na miokard, naglašava potrebu za razvojem novih metoda za boljerazumevanje srčanih funkcija.Data disertacija obuhvata analizu hipertrofične i dilatativnekardiomiopatije, kao i pridruženih bolesti koje se odnose na različite stepeneaortne stenoze i utiču na srčanu hipertrofiju. Kreirani su različititrodimenzionalni (3D) parametarski modeli leve srčane komore, kao i 3D modelirealne anatomske geometrije aortnog korena, i celog srca. Deo podataka izsprovedene kliničke studije i eksperimentalnih istraživanja kardiomiopatijeiskorišćeni su za razvoj i validaciju numeričkih modela, stratifikaciju rizikaod progresa kardiomiopatije, kao i za modeliranje dejstva različitih grupa lekovana srčanu funkciju.Kompjuterske simulacije sa 3D parametarskim modelima leve srčane komoreizvedene su pomoću spregnutih mikro- i makromodela, primenom metode konačnihelemenata i fluid-solid interakcijom. Interakcije lekova sa kardiomiocitimaodređene su u okviru eksperimentalnih istraživanja srčanog tkiva, a rezultati suimplementirani u spregnuti višeskalni model kako bi se odredio efekatrazličitih grupa lekova na 3D model leve komore srca. Implementirani su aktivnii pasivni modeli mišića. Na modelima realne anatomske geometrije simuliran jeuticaj različitih stepena aortne stenoze na odzive fluida i solida, i diskutovanaje njena povezanost sa hipertrofijom srca i aortopatijom. Predstavljene metode irezultati kompjuterskih simulacija za različite tipove kardiomiopatije ipridruženih kardiovaskularnih bolesti imaće značajan uticaj na kliničkesmernice i buduće pravce lečenja pacijenata.

Description (srp)

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Object languages

Serbian

Date

2023

Rights

Creative Commons License
This work is licensed under a
CC BY-SA 3.0 AT - Creative Commons Attribution-ShareAlike 3.0 Austria License.

http://creativecommons.org/licenses/by-sa/3.0/at/legalcode

Identifiers