Title (srp)

Efikasnot rastvora jona srebra na promene oksido - nitrozativnih parametara u terapiji bolesnika sa hroničnim oblikom parodontopatije

Author

Kovačević, Vladan, 1970-

Contributor

Lazić, Zoran, 1963-
Živković, Vladimir, 1984-
Lukić, Aleksandra, 1946-
Daković, Dragana, 1966-

Description (eng)

The aim of this study was to investigate the effect of an colloidal silver ions solution as a local adjuvant antiseptic in the treatment of chronic periodontitis compared with a chlorhexidine solution. The study monitored the effect of an colloidal silver ions solution on the values of oxidative and nitrosative status parameters in saliva and gingival crevicular fluid (GCF), such as: concentration of substances that reacts with thiobarbituric acid (TBARS), concentration of nitrite and nitrate (NO2 +NO3) , superoxide anion formation (O2.-), determination of total antioxidant capacity (TAS), total superoxide dismutase (tSOD) activity, catalase (CAT), glutathione peroxidase (GPx) and total glutathione (tGSH) content.The prospective cohort study was encompasseed 90 subjects (50 patients and 40 control subjects), of both sexes, aged 25-65 years, divided into four groups. The first group (BJS, n = 25) consisted of subjects with generalized chronic periodontitis, who were treated with a 5mg/ml of colloidal silver ions solution after scaling and root planing of periodontal pockets. This group was monitored before and after the therapy with this antiseptic. The second group of subjects (BCHX, n = 25) were treated with 0.2% chlorhexidine solution and also monitored before and after the therapy. The control group consisted of systemically healthy subjects, divided into two groups. One group received a colloidal silver ions solution (ZJS, n = 20), and the other a solution of chlorhexidine (ZCHX, n = 20) due to oral cavity rinsing.The monitored parameters related to the examination of the gingiva and periodontium (plaque index, gingival index, the clinical attachment level, the periodontal pocket depth), as well as the degree of oxidative and nitrosative activities in the saliva and GCF before and after periodontal therapy.The results of the study showed that a colloidal silver ions solution was at least equally effective as a chlorhexidine solution. Intensive use of silver ions solution in chronic generalized periodontitis patients showed great progress in causal therapy, because of its better tolerabilityKey words: periodontitis; oxidative stress; nitrosative status; scaling and root planing; antiseptics

Description (srp)

Cilj ovog istraživanja bio je ispitivanje uticaja vodenog rastvora jona srebra (JS) kaolokalnog adjuvantnog antiseptika u okviru kauzalne terapije parodontopatije upoređenju sa rastvorom hlorheksidina (CHX). U istraživanju je praćen uticaj vodenograstvora jona srebra na vrednosti parametara oksidativnog i nitrozativnog statusa usalivi i gingivalnoj crevikularnoj tečnosti (GCF), kao što su: koncentracijasupstanci koje reaguju sa tiobarbiturnom kiselinom (TBARS), koncentracija nitrita initrata (NO2+NO3), stvaranje superoksidnog anjona (O2.-), određivanje ukupnogantioksidativnog kapaciteta (TAS), aktivnost ukupne superoksid dizmutaze (tSOD), katalaze (SAT), glutation peroksidaze (GPx) i sadržaj ukupnog glutationa (tGSH).U prospektivnoj kohortnoj studiji uzelo je učešće 90 ispitanika (50 bolesnika i 40 kontrolnih subjekata), oba pola, dobi od 25-65 godina, podeljenih u četiri grupe. Prvugrupu (BJS, n=25) činili su ispitanici oboleli od generalizovane hroničneparodontopatije, koji su bili tretirani u okviru kauzalne terapije višeseansnommetodom kiretaže parodontalnih džepova i poliranjem površine korena zuba, uzispiranje parodontalnih džepova vodenim rastvorom jona srebra koncentracije 5mg/ml(JS). Ova grupa je bila praćena pre (BJS pre) i posle (BJS posle) terapije ovim antiseptikom.Druga grupa ispitanika (BCHX, n=25) je pored obrade parodontalnih džepova bila tretirana 0,2% rastvorom hlorheksidina (CHX) i takođe praćena pre (BCHX pre) i posle(BCHX posle) terapije. Kontrolnu grupu činili su sistemski zdravi ispitanici, podeljeni u dve grupe. Jedna grupa je dobijala rastvor jona srebra (ZJS, n=20), a druga rastvorhlorheksidina (ZCHX, n=20) za ispiranje usne duplje.Parametri koji su praćeni odnosili su se na ispitivanje gingive i parodoncijuma (plakideks, gingivalni indeks, nivo pripojnog epitela, dubina parodontalnog džepa), kao istepen oksidativnih, odnosno nitrozativnih aktivnosti u salivi i GCF pre i nakonparodontalne terapije. Rezultati sprovedene studije su pokazali da je vodeni rastvor srebrnih jona jednakoefikasan kao hlorheksidin, a obzirom na njegovu bolju podnošljivost intezivnaprimena srebrnih jona kod bolesnika sa hroničnom generalizovanom parodontopatijompokazuje veliki napredak u terapiji.

Description (srp)

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Object languages

Serbian

Date

2021

Rights

Creative Commons License
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CC BY-NC-SA 3.0 AT - Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Austria License.

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